People and projects

The Lab – 2022

2022 lab photo

The Lab – previous pictures

Lab 2018

Lab 2018

Lab focus on the X!

Lab focus on the X!

LSI Gallery

LSI Gallery

X inactivation Fans!

X inactivation Fans!

2017 UBC

2017 UBC

Calico Mask

Carolyn Brown

You can find a listing of Carolyn’s publications on Google Scholar (so much easier than searching Pubmed for C Brown!)

Ph.D., 1991, University of Toronto

Postdoctoral Fellowships:

Stanford University and
Case Western Reserve University

Current lab members

	Samantha Peeters, B.Sc. (Guelph) did her Ph.D. searching for the DNA elements allowing human genes to escape X-chromosome inactivation in collaboration with the Simpson and Wasserman labs at CMMT (BC Children’s Hospital). . She has stayed for a postdoctoral fellowship to develop mouse Embryonic Stem Cells that she can use to test pieces of human escape genes for their ability to maintain gene activity even when on an inactive chromosome! Sam was featured in Faculty of Medicine’s ‘Back to School’ site
	Karanveer Bhangu, B.Sc. (York) joined the lab in September 2021. He is currently using CRISPR to generate deletions of XIST in somatic cells.
Christine performing	Christine Yang, (M.Sc. UBC) did her M.Sc. on using DNA methylation to examine silencing of transgenes. She then undertook the lab’s first RNA and ChIP-seq studies (see Genome Biology paper) and has become the lab’s RIP-star.
Gashapon calico Brad brought from Japan	Sarah (B.Sc. Simon Fraser University) is the lab manager and is looking at XIST RNA:protein interactions.
image	Bronwyn Posynick
Seymour is not a calico, that’s unique to cats!	Maria Jose Navarro Cobos joined the lab in 2019 from Mexico.

Graduates and their Theses

Bradley Balaton, PhD., 2021 Bradley has moved to Belgium for his PDF	AN INVESTIGATION OF THE GENETIC AND EPIGENETIC FACTORS UNDERLYING ESCAPE FROM X–CHROMOSOME INACTIVATION
Thomas Dixon-McDougall, Ph.D., 2020 Tom has now moved to Boston for a PDF	FUNCTIONALITY OF DOMAINS OF XIST AND THEIR ROLE IN ESTABLISHING CHROMOSOME INACTIVATION
Samantha Peeters, Ph.D., 2019	Modelling human escape from X-chromosome inactivation in mouse
Andrew Chapman, M.Sc., 2013	Transcriptional regulation of the XIST locus
Angela Kelsey, M.Sc., 2013,	Mechanisms for XIST RNA cis-localization
Jakub Minks, Ph.D., 2012	Role of XIST and its interacting partners in gene silencing
Allison Cotton, Ph.D., 2012	Patterns of DNA methylation on the human X chromosome and use in analyzing X-chromosome inactivation
Christine Yang, M.Sc., 2012	DNA methylation demonstrates spread of X-chromosome inactivation to human transgenes
Nancy Thorogood, Ph.D., 2010	XIST/Xist Induced Epigenetic Events in Somatic Cells
Samuel Chang, Ph.D., 2009	Identification and characterization of cis-acting regulatory elements for human XIST
Desiree Quint, M.Sc., 2006	Aberrant Hypermethylation of Xq12 in Lymphoma
Ziny Yen, M.Sc., 2005	Comparative studies of X inactivation within eutheria
Jennifer Chow, Ph.D., 2003	XIST and its role in X-chromosome inactivation
Ed Kwok, M.Sc., 2002	XIST and macroH2A1.2 in hybrid cells
Cathy Anderson, Ph.D., 2002	Variable X inactivation of the human TIMP1 gene
Sanja Karulic, M.Sc., 2001	Studies of X-chromosome inactivation and identification of the Xist gene in the insectivore Scapanus orarius

Gone but not forgotten

Diane —– MITACS student, 2016

Molly — MITACS student, 2017

Kira — Undergraduate student, 2018 & 2019

Suria — MITACs student, 2019