You can find a listing of Carolyn’s publications on Google Scholar (so much easier than searching Pubmed for C Brown!)
Ph.D., 1991, University of Toronto
Stanford University and
Case Western Reserve University
Current lab members
Samantha Peeters, B.Sc. (Guelph) is a Ph.D. student identifying the DNA elements allowing human genes to escape X-chromosome inactivation. She is doing this by integration of human DNA into the mouse X chromosome in collaboration with the Simpson lab at CMMT. She is currently using CRISPR in a mouse embryonic stem cell line with two X chromosomes to generate a female cell line for targetting.
Thomas Dixon-McDougall, B.Sc. (Toronto) is a Ph.D. student studying the domains of the XIST RNA that are critical for the RNA to localize in cis, recruit chromatin modification, and silence flanking genes. He is currently using CRISPR to generate deletions along the X chromosome and uses FISH (he generated the ‘X’ on the header); immunohistochemistry; and allelic analyses to examine the impact of the deletions.
Bradley Balaton, B.Sc. (Saskatoon) is a Ph.D. student studying genes that are variable in their escape from X-chromosome inactivation, so that they are subject to inactivation in some females, but escape from inactivation in other females.
Christine Yang, (M.Sc. UBC) did her M.Sc. on using DNA methylation to examine silencing of transgenes. She then undertook the lab’s first RNA and ChIP-seq studies (see Genome Biology paper) and has become the lab’s RIP-star.
Sarah (B.Sc. Simon Fraser University) is the lab manager and is looking at XIST RNA:protein interactions.
Diana, a summer intern with the MITACs program, is studying the ‘boundaries’ between genes that are subject to silencing and those that escape X-chromosome inactivation.